Proline-Catalyzed Enantioselective Michael Additions of Ketones to Nitrostyrene
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- 1 December 2002
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2002 (01) , 0026-0028
- https://doi.org/10.1055/s-2002-19336
Abstract
Proline-catalyzed Michael additions of ketones to nitrostyrene were examined to obtain optically active γ-nitro ketones. The catalytic asymmetric 1,4-additions afforded the desired γ-nitro ketones in medium to excellent yields and up to 97% de of the syn-diastereomers and 76% ee.Keywords
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