Osteonecrosis of vertebrae in a child with acute lymphocytic leukaemia duringl-asparaginase therapy
- 1 December 1989
- journal article
- research article
- Published by Springer Nature in European Journal of Pediatrics
- Vol. 149 (3) , 162-163
- https://doi.org/10.1007/bf01958270
Abstract
We report a child with acute lymphocytic leukaemia who developed simultaneous osteonecrosis of vertebrae and cerebral thrombosis duringl-asparaginase therapy. Fibrinogen, antithrombin III and plasminogen were decreased. Fresh frozen plasma in addition to antithrombin III concentrates were used to replenish these haemostatic proteins.l-asparaginase induced coagulopathy may cause osteonecrosis.Keywords
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