Parkinson's Disease and Related α‐Synucleinopathies Are Brain Amyloidoses
- 1 June 2003
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 991 (1) , 107-110
- https://doi.org/10.1111/j.1749-6632.2003.tb07468.x
Abstract
A paradigm shift in understanding Parkinson's disease (PD) and related disorders is emerging from studies showing that alpha-synuclein (AS) gene mutations cause familial PD; AS is abnormally nitrated, phosphorylated, and ubiquitinated; AS forms neuronal and glial inclusions; AS fibrillizes in vitro; and AS transgenic animals develop neurodegeneration with AS amyloid inclusions. Thus, PD and related synucleinopathies are brain amyloidoses that may share similar mechanisms and targets for drug discovery.Keywords
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