Increased release of tumour cells by collagenase at acid pH: A possible mechanism for metastasis
- 1 December 1979
- journal article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 35 (12) , 1657-1658
- https://doi.org/10.1007/bf01953252
Abstract
The ability of collagenase to disaggregate a solid metastasizing lymphosarcoma has been shown to considerably increase with reducing environmental pH. It is suggested that this effect may be operating in vivo to release cells from a primary tumour.Keywords
This publication has 5 references indexed in Scilit:
- Radioiodination studies of tumour cell-surface proteins after different disaggregation proceduresBritish Journal of Cancer, 1977
- PROTEOLYTIC CONTROL OF COLLAGEN BREAKDOWNPublished by Elsevier ,1976
- Purification and partial characterization of collagenolytic enzymes from Clostridium histolyicumBiochemistry, 1968
- STUDIES ON HOMOTRANSPLANTABLE LYMPHOMAS IN HAMSTERS .I. HISTOLOGIC RESPONSES IN LYMPHOID TISSUES AND THEIR RELATIONSHIP TO METASTASIS1966
- Modifications of the Acid-Base Status of the Internal Milieu of TumorsJNCI Journal of the National Cancer Institute, 1965