A Crossover Study Comparing the Kinetics of Tc-99m-labeled Diethyl- and Diisopropyl-IDA

Abstract
Tc-99m-diisopropyl imidodiacetic acid [IDA] (DISIDA) and Tc-99m-diethyl (DE)-IDA were compared in each of 44 patients who had serum bilirubin levels ranging from normal to 50 mg/dl. Quantitative and qualitative analysis showed a significantly higher liver uptake relative to background for DISIDA. No significant differences between DISIDA and DE-IDA were found in the blood retention and rate of liver washout. Clinically, the diagnostic information received from both radiopharmaceuticals was essentially the same.
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