Anti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body disease.
Open Access
- 1 January 1989
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 52 (1) , 67-71
- https://doi.org/10.1136/jnnp.52.1.67
Abstract
Brainstem and cortical Lewy bodies in diffuse Lewy body disease show intense immunoreactivity to antibodies against ubiquitin. Quantitative studies show that the novel neuropathological technique of anti-ubiquitin immunocytochemistry is more than twice as sensitive as conventional haematoxylin and eosin stains in detecting cortical Lewy bodies. Anti-ubiquitin immunocytochemistry should be regarded as the method of choice for the diagnosis and quantification of diffuse Lewy body disease.This publication has 12 references indexed in Scilit:
- Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver diseaseThe Journal of Pathology, 1988
- Lewy bodies are ubiquitinatedActa Neuropathologica, 1988
- Ubiquitin-Mediated Pathways for Intracellular ProteolysisAnnual Review of Cell Biology, 1987
- CLINICAL AND PATHOLOGICAL FEATURES OF DIFFUSE CORTICAL LEWY BODY DISEASE (LEWY BODY DEMENTIA)Brain, 1987
- Dementia and Parkinson's disease associated with diffuse cortical Lewy bodies.1987
- The Lewy body in Parkinson's disease.1987
- Diffuse Lewy body diseaseActa Neuropathologica, 1987
- Reaction of Lewy bodies with antibodies to phosphorylated and non-phosphorylated neurofilamentsNeuroscience Letters, 1986
- Lewy Bodies of Parkinson's Disease Contain Neurofilament AntigensScience, 1983
- Lewy bodies in cerebral cortex. Report of three casesActa Neuropathologica, 1978