Activated T Lymphocytes Disappear from Circulation during Endotoxemia in Humans
- 1 May 2002
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 9 (3) , 731-735
- https://doi.org/10.1128/cdli.9.3.731-735.2002
Abstract
Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA + CD45RO − ) that were less likely to undergo apoptosis (CD28 + ), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA − CD45RO + ) as well as a phenotype linked to apoptosis (CD95 + CD28 − ). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.Keywords
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