Cytomegalovirus infections in adult T‐cell leukemia patients

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Abstract
Cytomegalovirus (CMV) infection frequently occurred in patients with malignant lymphoma of T‐cell origin, especially with adult T‐cell leukemia (ATL). This was evidenced by histopathological examination at autopsy, isolation of CMV, and detection of CMV antibodies that indicate recent or active infection. Cellular immune response was suppresssed in most ATL patients when examined by skin hypersensitivity reaction to purified protein derivatives (PPD), streptococcal antigens (SUPS), and phytohaemoagglutinin (PHA). None of the CMV‐positive patients reacted to them. Thus, the presence of tumor cells of T‐cell origin and the absence of skin hypersensitivity reaction seem to be risk factors for CMV infection. Each CMV isolate exhibited unique DN A fingerprints, suggesting that cross‐infection of CMV did not occur among the ATL patients on the same ward.

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