Primary Antiphospholipid Syndrome
Open Access
- 1 January 2020
- book
- Published by Frontiers Media SA
Abstract
Antiphospholipid syndrome (APS) is defined by the presence of thrombosis or gestational morbidity in people harboring anti-phospholipid antibodies. APS was initially described in patients with concomitant autoimmune diseases, such as Systemic Lupus Erythematosus (SLE), and is widely studied in this context. Shortly after APS was described, it was found that it could also appear in patients with no preceding history of autoimmune disease. This was defined as the primary form of APS (P-APS). Therefore, two basic forms of APS were subsequently established: P-APS and APS related to other systemic autoimmune diseases (SAD-APS).The epidemiology, pathogenesis and characteristics of P-APS are much less characterized in comparison with SAD-APS. This is since, in the case of SAD-APS, both clinical and analytical data (and even stored serum samples), are available prior to the onset of the syndrome. However, P-APS is an entity that can appear sporadically in people with no previous history of disease. Generally, P-APS diagnosis is made only after ruling out other possible causes and many patients remain un-diagnosed. In recent years, P-APS, outside the context of systemic autoimmune diseases, is being diagnosed at an increasing frequency in both pre-symptomatic patients and in patients with other chronic non-autoimmune diseases (e.g. renal and cardiac failure).The aim of this Research Topic is to gather a collection of basic and translational research studies and the most recent clin...This publication has 0 references indexed in Scilit: