Tissue Distribution of Radioactivity in Rats given Tritiated Analogues of Hepatotoxic Pyrrolizidine Alkaloids
- 1 January 1977
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 7 (11) , 665-670
- https://doi.org/10.3109/00498257709038696
Abstract
1. [3H]Retronecine 7,9-bis-N-ethylcarbamate (RC) given intravenously (120 mg/kg) to male rats showed similar tissue distribution of radioactivity to that after an equally hepatotoxic dose (40 mg/kg) of [3H]synthanecine A bis-N-ethylcarbamate (SAC), but the 3H in most tissues after 3H-SAC was about double that after 3H-RC. 2. Concentrations of radioactivity were initially highest in liver and lung, but were higher in lung after 3H-RC than after 3H-SAC, reflecting the higher pneumotoxicity of the former. Concentrations of radioactive metabolites strongly attached to liver tissue were approx. the same 1 day after similarly hepatotoxic doses of either compound. 3. Excretion of radioactivity from 3H-RC was about double that from 3H-SAC in urine, and half that in faeces during the first day.This publication has 7 references indexed in Scilit:
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