Experiences with 2-Hydroxystilbamidine in Systemic Sporotrichosis

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Abstract
Systemic sporotrichosis involving the skin, bones, viscera, and central nervous system is rare.* Recent reviews of sporotrichosis make only passing mention of this unusual syndrome. Collins3has reported the case of a 67-year-old man with disseminated cutaneous and visceral lesions. Clinically, except for the cutaneous involvement, the patient was asymptomatic. Enlargement of the liver and spleen was noted on physical examination. At necropsy, however, multiple visceral lesions were observed in the form of microscopic miliary granulomas. The skin, lungs, spleen, liver, kidneys, adrenals, cerebral cortex, and bone marrow were involved. Cawley1has reported the case of a 70-year-old man who had multiple disseminated subcutaneous gummatous lesions and probable osseous lesions and who apparently was cured with iodides. Moore and Kile14reported a case of generalized subcutaneous gummatous ulcerating sporotrichosis with skin and pulmonary lesions which apparently cleared up with iodide therapy. Involvement of the central nervous system

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