Analysis of H-2 determinants recognized during the induction of H-Y-immune cytotoxic T cells by monoclonal antibodies in vitro

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Abstract
Monoclonal antibodies directed to the D region of H-2k when present during in vitro culture inhibit the generation of CBA/H and C3H.H-2.degree. [mouse] H-Y-immune cytotoxic T cells. Monoclonal antibodies directed to the I-Ak and I-Ek region specifically inhibited induction of CBA/H H-Y-immune cytotoxic T cells only when they were present simultaneously in culture. These findings show T helper cell requirement for CBA/H H-Y-immune cytotoxic T cell induction, and suggest that 2 I region-coded restriction antigens for T helper cells are involved.