Enhancement of Mouse Thymus Cells Response to Periodate Treatment by a Soluble Factor
Open Access
- 1 December 1972
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 109 (6) , 1278-1281
- https://doi.org/10.4049/jimmunol.109.6.1278
Abstract
Mouse lymph node and spleen lymphocytes are stimulated by sodium periodate (NaIO4) treatment, whereas mouse thymus cells show a minimal response. Hydrocortisone-resistant thymus cells are much more responsive to phytohemagglutinin than NaIO4 treatment. Thymus cells are rendered highly responsive to NaIO4 treatment upon addition of cell-free supernatants of mouse spleen cell and macrophage cultures. Treatment of mouse spleen cells and macrophages with NaIO4 stimulates the production of the enhancing factor for thymus cell response.Keywords
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