NEMATOSPIROIDES DUBIUS: SUSCEPTIBILITY TO INFECTION AND THE DEVELOPMENT OF RESISTANCE IN HYPOTHYMIC (NUDE) BALB/c MICE
- 1 October 1978
- journal article
- research article
- Published by Wiley in Immunology & Cell Biology
- Vol. 56 (5) , 561-570
- https://doi.org/10.1038/icb.1978.62
Abstract
BALB/c-nu/nu mice and their intact nu/+ littermates are equally susceptible to infection with third-stage larvae of Nematospiroides dubius. Unlike their heterozygous littermates. however, the nu/nu mice are unable to form granulomata in the intestinal wall and become only partially resistant to rechallenge. Following two or more infections, nu/nu mice maintain a high burden of adult intestinal worms, whereas worms are lost from immune nu/+ mice. Studies in T cell-injected nu/nu mice suggest that a full complement of T cells is needed to develop maximum resistance against the infective third-stage larvae and to expel adult worms. Measurement of serum immunoglobulin levels indicate that infected nu/+ mice have very high levels of IgG1 whereas the levels of IgG2a are reduced. In infected T cell-injected nu/nu mice, IgG1 levels increase with the number of T cells injected, whereas IgG2a levels are variable but always higher than in infected nu/+ mice.Keywords
This publication has 1 reference indexed in Scilit:
- Altered Schistosome Granuloma Formation in Nude Mice *The American Journal of Tropical Medicine and Hygiene, 1977