ACCELERATED HEALING OF BENIGN GASTRIC-ULCERS WITH A SINGLE EVENING DOSE OF FAMOTIDINE

  • 1 January 1985
    • journal article
    • research article
    • Vol. 115  (14) , 484-488
Abstract
An 8 wk, double-blind randomized, placebo-controlled multicenter trial was conducted in Austria, Germany and Italy to determine whether famotidine would speed healing and relief of symptoms in patients with benign gastric ulcer. Of the 131 patients who completed the trial, 66 received 40 mg famotidine in the evening and 65 placebo. At 4, 6 and 8 wk after entry, ulcers healed in a higher percentage of patients treated with famotidine than of those treated with placebo (47%, 70%, 91% vs. 32%, 49%, 61%). In the famotidine group healing occurred significantly more often after 6 and 8 wk (P < 0.05 and P < 0.01, respectively). Famotidine was superior to placebo in relieving ulcer symptoms. The proportion of patients receiving additional antacid therapy was significantly lower in the famotidine group. The new H2-receptor antagonist famotidine significantly speeds the healing of benign gastric ulcers in a single evening dose.

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