A cyclic AMP-activated K+ channel in Drosophila larval muscle is persistently activated in dunce.
- 15 January 1991
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 88 (2) , 557-560
- https://doi.org/10.1073/pnas.88.2.557
Abstract
Single-channel recording from longitudinal ventrolateral Drosophila larval muscle reveals the presence of a potassium-selective channel that is directly and reversibly activated by cAMP in a dose-dependent fashion. Activation is specific and it cannot be mimicked by a series of agents that include AMP, cGMP, ATP, inositol trisphosphate, and Ca2+. Channel current records obtained from larval muscle in different dunce mutants possessing abnormally high levels of cAMP show that, in the mutants, the channel displays an increased probability of opening.Keywords
This publication has 24 references indexed in Scilit:
- L‐Glutamate activates excitatory and inhibitory channels in Drosophila larval muscleFEBS Letters, 1989
- Ion Channels in DrosophilaAnnual Review of Physiology, 1988
- Activation by divalent cations of a Ca2+-activated K+ channel from skeletal muscle membrane.The Journal of general physiology, 1988
- Neurogenetic Dissection of Learning and Short-Term Memory in DrosophilaAnnual Review of Neuroscience, 1988
- Single-Channel and Genetic Analyses Reveal Two Distinct A-Type Potassium Channels in DrosophilaScience, 1987
- Genetics and Molecular Biology of Ionic Channels in DrosophilaAnnual Review of Neuroscience, 1986
- Phosphorylation of Ion channelsThe Journal of Membrane Biology, 1985
- Genetic modification of potassium channels in Drosophila Shaker mutantsNature, 1981
- Dunce mutants of Drosophila melanogaster: mutants defective in the cyclic AMP phosphodiesterase enzyme system.The Journal of cell biology, 1981
- Genetic alteration of nerve membrane excitability in temperature-sensitive paralytic mutants of Drosophila melanogasterNature, 1980