tRNA processing in human mitochondrial disorders
- 1 January 1996
- journal article
- review article
- Published by Springer Nature in Molecular Biology Reports
- Vol. 22 (2-3) , 187-193
- https://doi.org/10.1007/bf00988727
Abstract
Many human mitochondrial disorders are associated with mutations in tRNA genes or with deletions of regions containing tRNA genes, all of which may be suspected to play a role in recognition by RNase P. Here we describe the analysis of five such mutations. The results presented here demonstrate that none of thse mutations result in errors in RNase P function. Further studies of mutations in tRNAs need to be pursued to elucidate the identity elements for RNase P function in mammalian mitochondria.Keywords
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