Chick cephalogenesis. The normal development of the cephalic region of stages 3 through 11 chick embryos

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Abstract
The cephalogenesis of chick embryos was studied at stages 3 through 11 inclusive. Ten embryos were examined at each stage. Particular attention was paid to the time of appearance of the prechordal plate mesoderm and cephalic notochord. It was found that the presumptive neural ectoderm begins to differentiate to form medullary plate as soon as it becomes associated with the chordamesoderm. Histological studies revealed the similarity of the notochord underlying the presumptive forebrain and midbrain regions, and the differences between this notochord and that associated with the hindbrain. These differences included the notochord histology and time of separation of the notochord from entoderm and neural ectoderm.