Generalized Malignant Acanthosis Nigricans and Primary Fibrinolysis

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Abstract
Generalized acanthosis nigricans is frequently regarded as a cutaneous marker of malignant disease, most often adenocarcinoma.1 Herein, an unusual case of generalized malignant acanthosis nigricans (GMAN) that accompanied squamous cell carcinoma of the uterine cervix is reported. The occurrene of primary fibrinolysis, a rare disorder sometimes associated with hematologic malignant neoplasms, prostate carcinoma, or pancreatic carcinoma,2 has not, to our knowledge, been reported previously in these circumstances. Report of a Case A 58-year-old woman with a three-year history of stage Ib squamous cell carcinoma of the uterine cervix was initially seen with erythroderma of several months' duration. During a threemonth period, we noticed a gradual onset of skin thickening and hyperpigmentation on the whole body (Fig 1), which was particularly severe in the flexural areas. There was progressive hair loss (Fig 2) and thickening, with white discoloration of the nails. Physical examination disclosed no other pathologic findings. A

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