Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
- 1 May 1997
- journal article
- Published by Springer Nature in Nature
- Vol. 387 (6628) , 49-55
- https://doi.org/10.1038/387049a0
Abstract
Normal mammalian growth and development are highly dependent on the regulation of the expression and activity of the Myc family of transcription factors. Mxi1-mediated inhibition of Myc activities requires interaction with mammalian Sin3A or Sin3B proteins, which have been purported to act as scaffolds for additional co-repressor factors. The identification of two such Sin3-associated factors, the nuclear receptor co-repressor (N-CoR) and histone deacetylase (HD1), provides a basis for Mxi1/Sin3-induced transcriptional repression and tumour suppression.Keywords
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