Distribution of Sulfur in Regenerating Wound Tissue

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Abstract
Following pre-labeling of labile body proteins by injection of S35-L-methione and subsequent wounding, regenerating tissue was removed at 4 and 6 day intervals, fractionated, and assayed chemically and radioactively for bound and non-protein bound cystine and methionine, and for free and mucopolysaccharide sulfate. Specific activity of unfractionated cystine and methionine from the wound was studied at intervals over 3 weeks. The data indicate that, for the first 6 days after injury, S35, administered as S35-L-methionine 2 days prior to wounding, is incorporated into wound tissue in large measure as protein-bound methionine and cystine. During the interval studied, administered methionine-S35 is not a precursor for wound tissue mucopolysaccharide sulfate.

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