The Developmental Pattern of Somatostatin in the Embryonic and Fetal Rat Pancreas
- 1 September 1977
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 101 (3) , 825-829
- https://doi.org/10.1210/endo-101-3-825
Abstract
The ontogenesis of immunoreactive somatostatin in the embryonic and fetal rat pancreas has been measured by radioimmunoassay following acid extraction. Somatostatin (GIF) is detectable at 14 days gestation at a concentration of 1.6 × 10−3 ng/pancreas. At term the content is 3.8 ng/pancreas, by 2 days neonatally, 8.3 ng/pancreas, and in the adult rat, 71 ng/pancreas though the concentration (expressed per μg DNA) is constant from 14–19 days of gestation and reaches a level characteristic of the fully differentiated pancreas by birth. The detection of GIF in cultured pancreatic explants in the absence of innervation indicates that synthesis can occur independent of neural influence.Keywords
This publication has 2 references indexed in Scilit:
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- Epitheliomesenchymal interaction in pancreatic morphogenesisDevelopmental Biology, 1962