The interaction of ethanol and amphetamine metabolism
- 1 November 1970
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 22 (11) , 828-831
- https://doi.org/10.1111/j.2042-7158.1970.tb08447.x
Abstract
Ethanol, 1, 3, and 5 g/kg, depresses the hydroxylation of amphetamine by the rat in vivo. At 5 g/kg, ethanol does not affect the hydroxylation of acetanilide or biphenyl in vivo. Amphetamine hydroxylation is unaffected by phenobarbitone or benzo[a]pyrene pretreatment but is depressed by pretreatment with 2-diethylaminoethyl-2, 2-diphenyl-valerate (SKF 525-A), 2, 4-dichloro-6-phenylphenoxyethylamine (DPEA), and 2, 4-dichloro-6-phenylphenoxy-NN-diethylethylamine (Lilly 18947).Keywords
This publication has 15 references indexed in Scilit:
- The effect of ethanol on the metabolism of amphetamine by the ratJournal of Pharmacy and Pharmacology, 1969
- Inhibition of ethanol metabolism in vivo by administration of pyrazoleBiochemical Pharmacology, 1969
- Inhibition of the hepatic metabolism of amphetamine by desipramineBiochemical Pharmacology, 1969
- Factors affecting the rate of disappearance of amphetamine in ratsInternational Journal of Neuropharmacology, 1969
- A fluorimetric study of the hydroxylation of biphenyl in vitro by liver preparations of various speciesBiochemical Journal, 1965
- THE EXCRETION OF DEXAMPHETAMINE AND ITS DERIVATIVESBritish Journal of Pharmacology and Chemotherapy, 1965
- Metabolism of Tranylcypromine-C14 and dl-Amphetamine-C14 in the RatJournal of Medicinal Chemistry, 1963
- A new potent inhibitor of microsomal drug-metabolizing enzymes 2:4-dichloro-6-phenylphenoxyethylamine hydrochloride (DPEA) (LILLY 32391)Biochemical Pharmacology, 1963
- Factors Influencing Drug MetabolismPublished by Elsevier ,1962
- IN VITRO INHIBITION OF LIVER ALDEHYDE DEHYDROGENASE BY TETRAETHYLTHIURAM DISULPHIDEJournal of Pharmacy and Pharmacology, 1951