Surface Behaviors of Nucleic Acid Base-Containing Lipids in Monolayer and Bilayer Systems

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Abstract
Three kinds of nucleic acid base-containing lipids were synthesized and the surface behaviors of these compounds in monolayer and bilayer systems were examined. In the monolayer systems, the addition of a complementary nucleoside to a subphase solution extended the monolayer much more efficiently than that of other nucleosides because of hydrogen bonding between a pair of complementary bases. In the monolayer and bilayer systems, the photodimerization reaction of a thymine ring was confirmed by the change in the surface pressure of the monolayer and the decrease in absorbance and the broadening of the phase-transition peak in the DSC curve of the liposome solution.