Disappearance of Isotopically Labeled Gold Colloids from the Circulation of the Dog

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Abstract
Immediately following intraven. injn. of radloactlvely labeled colloidal gold particles in the dog the circulatory level drops exponentially with time, the half value time (T1/2) being about 1.5 min. Low residual level is reached in 10-20 min. showing occasional fluctuations. High activity is then found in the liver (Sheppard, Wells, Hahn and Goodell, Jour. Lab. and Clin. Med. 32:274). Inserting reasonable values into the formula T1/2 = 0.69B/KQ, where B is the total blood volume, Q the rate of blood supply to the liver and K the fraction removed on a single passage through the organ (assumed as unity), an entirely reasonable result is obtained for the liver blood supply rate.