Evaluation of the Effects of Antiepileptic Drugs on Sleep-Wakefulness Patterns following 1 Night Total Sleep Deprivation in Epileptic Patients
- 1 January 1985
- journal article
- research article
- Published by S. Karger AG in Neuropsychobiology
- Vol. 13 (4) , 201-205
- https://doi.org/10.1159/000118188
Abstract
Sleep-wakefulness patterns recorded following 1 night total sleep deprivation were studied in 15 normal subjects and in 252 epileptic patients. The patients were taking various types and combinations of antiepileptic medication. Sleep deprivation caused a reduction in sleep latency and an increase in NREM stage 3 + 4 sleep. This effect persisted in patients treated with valproate sodium and/or carbamazepine. In patients treated with diphenylhydantoin light NREM 1 + 2 sleep increased. In those treated with antiepileptics + chlorazepate, both an increase in NREM 1 + 2 and NREM 3 + 4 sleep was seen. The former probably reflects a benzodiazepine effect, the latter is due to a sleep deprivation effect. In patients treated with antiepileptics + clonazepam, a benzodiazepine effect predominated.Keywords
This publication has 2 references indexed in Scilit:
- EEG Findings and Sleep DeprivationEuropean Neurology, 1980
- Visual and computer-based analysis of 24 h sleep-waking patterns in the dogElectroencephalography and Clinical Neurophysiology, 1979