HRE 664, a new parenteral penem. I. Antibacterial activity in vitro.
- 31 December 1986
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 40 (5) , 660-667
- https://doi.org/10.7164/antibiotics.40.660
Abstract
The new penem antibiotic HRE 664 displays potent antibacterial activity in vitro against a broad spectrum of clinically relevant bacterial strains including Gram-negative and Gram-positive aerobes and anaerobes. With an MIC 90% of 0.43 .mu.g/ml, it is also active against methicillin-resistant staphylococci. HRE 664 is extremely stable against .beta.-lactamases, it binds preferentially to the penicillin-binding proteins 2, 3, 5 and 6 of Escherichia coli.This publication has 2 references indexed in Scilit:
- Comparison of in vitro activity of FCE 22101, a new penem, with those of other beta-lactam antibioticsAntimicrobial Agents and Chemotherapy, 1983
- Sch 29482--a novel penem antibiotic: an in-vitro comparison of its activity with other -lactamsJournal of Antimicrobial Chemotherapy, 1982