DNA nucleotide sequence analysis of the immediate-early gene of pseudorabies virus
- 1 January 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 17 (12) , 4637-4646
- https://doi.org/10.1093/nar/17.12.4637
Abstract
The complete DNA sequence coding for the immediate-early protein (IE180) of pseudorabies virus was determined. The coding region of IE180 is 4380 nucleotides for 1460 amino acid residues. G+C content of the non-coding portion of the IE gene is 70.3% while the G+C content of the coding portion is considerably higher at 80.1%. Correspondingly, codons consisting mainly of Gs and Cs are favored. Clusters of amino acid homologies are observed among IE180 of pseudorabies virus, ICP4 of herpes simplex virus type-1 and IE140 of varicella-zoster virus, and are organized similarly in all three polypeptides. Functions exhibited by IE180 are assigned, tentatively, to structural domains of the molecule by analogy to the HSV-1 ICP4 polypeptide.Keywords
This publication has 26 references indexed in Scilit:
- Identification of a 17000 Molecular Weight Antigenic Polypeptide in Transmissible Gastroenteritis Virus-infected CellsJournal of General Virology, 1986
- DNA Sequence of the Major Inverted Repeat in the Varicella-Zoster Virus GenomeJournal of General Virology, 1985
- Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencingGene, 1984
- Characterization of the immediate-early functions of pseudorabies virusVirology, 1983
- Transcriptional activation of cloned human β-globin genes by viral immediate-early gene productsCell, 1983
- Location and Orientation of Homologous Sequences in the Genomes of Five HerpesvirusesJournal of General Virology, 1983
- Localization of the regions of homology between the genomes of herpes simplex virus, type 1, and pseudorabies virusVirology, 1983
- Distribution of Sequences Homologous to the DNA of Herpes Simplex Virus, Types 1 and 2, in the Genome of Pseudorabies VirusIntervirology, 1980
- Studies on the relatedness of herpes viruses through DNA · RNA hybridizationBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1972
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970