STUDY OF CRITICAL BACTERIAL INOCULUM TO CAUSE A STIMULUS TO WOUND-HEALING

  • 1 January 1977
    • journal article
    • research article
    • Vol. 144  (3) , 347-350
Abstract
In studies in which wounds infected with gram-negative bacteria had greater tensile strength than uninfected wounds, the inoculum was .apprx. 2 .times. 107 organisms. Rat laparotomy wounds were swabbed with inocula of from 102-109 Escherichia coli. Only with inocula of .gtoreq. 106 microbes were all parts of all wounds infected by gross inspection. All wounds inoculated with .gtoreq. 107 organisms were significantly stronger than the wounds of a control group on the 14th day. Smaller inocula (103-106) often resulted in stronger wounds. Increased tensile strength in infected wounds may result from an exaggerated inflammatory response causing increased granulation and possibly faster healing.

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