Case 46231

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Abstract
Presentation of Case First admission. A sixty-two-year-old spinster entered the hospital for study of osteolytic lesions.Seven years previously she experienced symptoms of sciatica in the right leg, and x-ray films of the bones revealed diffuse osteolytic lesions. A biopsy specimen of a rib at another hospital showed metastatic carcinoma, "possibly of breast or thyroid origin." Physical examination revealed questionable retraction of the left nipple, but no nodule was felt in either breast, and no axillary nodes were palpable. Ethinyl estradiol therapy, 3 mg. daily by mouth, was begun. Two months later x-ray films of the skeleton again demonstrated . . .

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