Reductive ring opening of thiazoles

Abstract
The course of the reductive ring‐opening reactions of 2‐mercapto‐, 2‐hydroxy, 2‐amino‐, 2‐methylamino‐ and 2‐dimethylamino‐4‐methylthiazoles with sodium in liquid ammonia, yielding substituted propenethiolates, has been found to depend on the nature of the hetero substituent. The mechanism of the ring opening is discussed.

This publication has 6 references indexed in Scilit: