Change of ras-Transformed NRK-Cells Back to Normal Morphology by Mycalamides A and B, Antitumor Agents from a Marine Sponge.
- 1 January 1991
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 39 (8) , 2152-2154
- https://doi.org/10.1248/cpb.39.2152
Abstract
Mycalamide A and mycalamide B, isolated as antiviral and antitumor agents from a New Zealand sponge of the genus Mycale, converted the morphology of ras-transformed NRK-cells to normal morphology at 10 and 1 ng/ml, respectively. The effect on protein synthesis suggests that these agents converted the morphology by preferentially inhibiting the biosynthesis of p21 protein.Keywords
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