L-Deprenil, A Selective Monoamine Oxidase Type B Inhibitor, in the Treatment of Depression: A Double Blind Evaluation
- 1 May 1983
- journal article
- research article
- Published by Royal College of Psychiatrists in The British Journal of Psychiatry
- Vol. 142 (5) , 508-511
- https://doi.org/10.1192/bjp.142.5.508
Abstract
Summary: In a double blind controlled study, 14 affectively ill patients (2 bipolars, 12 unipolars) were randomly allocated to L-Deprenil treatment (an irreversible selective MAO-B inhibitor without “cheese effect”) and 13 patients (3 bipolars, 10 unipolars) to placebo only. Patients on L-Deprenil showed a significantly greater clinical improvement than placebo patients. A positive relationship was found between clinical improvement and degree of platelet MAO inhibition in patients treated with L-Deprenil.This publication has 16 references indexed in Scilit:
- Antidepressant potentiation of 5-hydroxytryptophan by L-deprenil in affective illnessJournal of Affective Disorders, 1980
- L-deprenyl, a selective monoamine oxidase type-b inhibitor in endogenous depressionLife Sciences, 1980
- L-deprenyl treatment of on-off phenomena in Parkinson's diseaseJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1978
- Overview of present day treatment of Parkinson's diseaseJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1978
- On the mode of action of L-deprenyl in the human central nervous systemJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1978
- MONOAMINE-OXIDASE INHIBITORS AND PROLACTIN SECRETIONThe Lancet, 1977
- Dopamine is a monoamine oxidase B substrate in manNature, 1977
- Diagnostic Criteria for Use in Psychiatric ResearchArchives of General Psychiatry, 1972
- TYRAMINE IN CHEESE RELATED TO HYPERTENSIVE CRISES AFTER MONOAMINE-OXIDASE INHIBITIONThe Lancet, 1965
- A RATING SCALE FOR DEPRESSIONJournal of Neurology, Neurosurgery & Psychiatry, 1960