IMMUNOELECTRON MICROSCOPY OF HUMAN CHORIONIC VILLUS IN SEARCH OF BLOOD-GROUP A AND B ANTIGENS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 35  (6) , 530-536
Abstract
The chorionic villi of placentas, after 10-40 wk of gestation, were examined for A and B blood group antigens with an immunoferritin technique. No specific ferritin attachment was shown on the plasma membrane of the villous trophoblasts. After trophoblast cell-surface mucosubstances (perhaps the barrier of the placental antigenicity) were digested with several enzymes, such as neuraminidase, hyaluronidase, chondroitinase ABC, pepsin, trypsin and Pronase, no ferritin tagging was observed on the plasma membrane of the villous trophoblasts. The failure to detect the A and B blood group antigens was not due to the masking of antigens by a mucosubstance coating the trophoblasts, but was due to the intrinsic deficit of those antigens in the plasma membrane of the human trophoblasts.

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