Megaloblastic Anemia Possibly Induced by Triamterene in Patients with Alcoholic Cirrhosis
- 1 January 1968
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 68 (1) , 168-173
- https://doi.org/10.7326/0003-4819-68-1-168
Abstract
Both patients had low serum folate levels. One patient was critically ill, but survived when triamterene was stopped and folic and folinic acids were administered. Because triamterene is a folic acid antagonist in vitro, it may precipitate megaloblastic anemia in alcoholic cirrhosis by inhibiting the utilization of folic acid in the presence of low stores of folic acid.Keywords
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