Synthesis of L-glutamic acid labelled stereospecifically at C-3 with deuterium and non-stereospecifically at C-4 with tritium
- 1 January 1983
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 10,p. 2387-2392
- https://doi.org/10.1039/p19830002387
Abstract
(2S,3S)-[3-2H1]-, (2S,3R)-[2,3-2H2]-, (2S,3S,4RS)-[3-2H1,4-3H1]-, and (2S,3R,4RS)-[2,3-2H2,4-3H1]-Glutamic acids have been synthesised from the corresponding labelled aspartic acids. The route involves a step where Wolff rearrangement occurs with retention of stereochemistry at a primary migrating chiral centre. The stereochemistry at C-3 of the glutamic acids has been verified by degradation to the corresponding stereospecifically labelled [2H1] succinic acids.This publication has 0 references indexed in Scilit: