Immunological Sequelae of Trichinella spiralis Infection in Mice: Effect on the Antibody Responses to Sheep Erythrocytes and Japanese B Encephalitis Virus
- 1 June 1975
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 11 (6) , 1306-1311
- https://doi.org/10.1128/iai.11.6.1306-1311.1975
Abstract
Immunosuppression of the antibody response to Japanese B encephalitis (JBE) virus and sheep erythrocytes (SRBC) was observed in mice infected with Trichinella spiralis . This suppression was paralleled by the presence of fewer antibody-forming cells to SRBC in the spleens of parasitized mice. Both primary and secondary complement-fixing antibody responses to JBE virus were suppressed, but the development of immunological memory was not affected. Parasitized mice demonstrated a normal blastogenic response to phytohemagglutinin and normal serum clearance rate of injected 125 I-labeled immunoglobulin G 2b , although the size of the extravascular fluid compartment was significantly increased. The data presented here and in previous reports suggest that sequential antigenic competition is a possible explanation for the humoral immunosuppression to heterologous antigens caused by T. spiralis infection.Keywords
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