Autoantibodies in Alopecia Areata

1 July 1975

journal article
research article
Published by American Medical Association (AMA) in Archives of Dermatology

Vol. 111 (7) , 927-928
https://doi.org/10.1001/archderm.1975.01630190117023

Abstract

To the Editor.— Many authors have reported the association of alopecia areata (AA) with one or more autoimmune diseases, such as Addison disease,^1-3pernicious anemia,^2,3,5,8idiopathic hypoparathyroidism,^1-5premature ovarian failure,^3,5ulcerative colitis,^6,7hypothyroidism,^3,8some cases of diabetes mellitus,⁸and moniliasis.^1-5 No notable incidence of thyroid antibodies was found by Cunliffe et al⁹in 71 patients with isolated AA. On the contrary, Kern et al¹⁰reported a high incidence of thyroid, adrenal, and parietal cell antibodies. We performed an immunological study of 52 patients with isolated AA to clarify the possible relationship between AA and autoimmunity. Subjects and Methods.— Fifty patients with typical cases of AA and two with alopecia totalis were examined. None of them had previously received corticosteroid therapy. Of the 52 patients, who ranged from 3 to 63 years in age, 33 were men and 19 were women.

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