Modified screen-printed electrodes for the investigation of the interaction of non-electroactive quinazoline derivatives with DNA
- 7 June 2000
- journal article
- research article
- Published by Springer Nature in Analytical and Bioanalytical Chemistry
- Vol. 367 (4) , 364-368
- https://doi.org/10.1007/s002160000388
Abstract
Five morpholino-quinazoline derivatives have been investigated voltammetrically using a competition with the tris(o-phenanthroline) cobalt(III) redox marker for the accumulation at dsDNA modified screen-printed electrodes. An association of quinazolines with DNA was observed at the modified electrodes polarized by the negative potential of –0.4 V vs. Ag/AgCl. This was confirmed by a potentiometric stripping analysis based on the DNA guanine signal. Calibration curves for quinazolines within a concentration range of μmol/L were obtained with DP voltammetry using 5 × 10–7 mol/L Co(phen)3 3+ marker. The quinazolines exhibit no effect on the DNA complex with the fluorescent thiazole orange derivative TO-PRO-3. The role of the accumulation potential in the association interaction with DNA is discussed.Keywords
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