Cytotoxic antibody complicating platelet support in acute leukemia. Response to chemotherapy
- 30 August 1976
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 236 (9) , 1044-1046
- https://doi.org/10.1001/jama.236.9.1044
Abstract
Lymphocytotoxic or thrombocytolytic antibodies were detected in 11 of 25 thrombocytopenic patients receiving repeated platelet transfusions. Platelet survival times were reduced in these patients (half-life [T/2], 32 h) as compared to patients without antibody (T/2, 51 h, P < .05). In 1 woman with acute myeloblastic leukemia and potent platelet antibody, combination chemotherapy resulted in a profound decrease in circulating .gamma.-globulin and concurrent disappearance of the cytotoxic antibody. The survival of transfused platelets in this patient was dramatically improved, and bleeding was controlled.This publication has 2 references indexed in Scilit:
- Platelet Transfusions From HL-A Compatible Unrelated Donors to Alloimmunized PatientsAnnals of Internal Medicine, 1974
- Platelet Sequestration in Man. I. Methods*Journal of Clinical Investigation, 1964