Chlorpropamide-Induced Hyponatremia
- 1 November 1976
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 43 (5) , 1085-1087
- https://doi.org/10.1210/jcem-43-5-1085
Abstract
A 29-year-old woman with severe idiopathic diabetes insipidus, while being treated by a combination of chlorpropamide and chlorothiazide, developed the syndrome of inappropriate secretion of ADH (SIADH) following an overdose of chlorpropamide. The syndrome resolved as the serum chlorpropamide level fell. This report demonstrates that a chlorpropamide-induced SIADH can occur in a patient with idiopathic diabetes insipidus, and it appears that the antidiuretic effect of the drug is dose-related.Keywords
This publication has 3 references indexed in Scilit:
- Chlorpropamide-Induced Water Retention in Patients with Diabetes MellitusAnnals of Internal Medicine, 1971
- Recognition of Partial Defects in Antidiuretic Hormone SecretionAnnals of Internal Medicine, 1970
- Hyponatremia Due to ChlorpropamideAnnals of Internal Medicine, 1970