Inhibition of human α-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate

This publication has 14 references indexed in Scilit:

• Structural Basis of the Thrombin Selectivity of a Ligand That Contains the Constrained Arginine Mimic (2S)-2-Amino-(3S)-3-(1-carbamimidoyl- piperidin-3-yl)-propanoic Acid at P1
  Journal of Medicinal Chemistry, 2000
• X-Ray Crystallographic Analyses of Human α-Thrombin Complexed to Peptidyl Aminophosphonates: Evidence of a Binding Mechanism
  Phosphorus, Sulfur, and Silicon and the Related Elements, 1999
• Crystallographic Structures of Human α-Thrombin Complexed to Peptide Boronic Acids Lacking a Positive Charge at P1. Evidence of Novel Interactions
  Journal of the American Chemical Society, 1997
• Structure of a specific acyl-enzyme complex formed between β-casomorphin-7 and porcine pancreatic elastase
  Nature Structural & Molecular Biology, 1997
• Inhibition of Trypsin and Thrombin by Amino(4-amidinophenyl)methanephosphonate Diphenyl Ester Derivatives: X-ray Structures and Molecular Models^,
  Biochemistry, 1996
• Episelection: Novel Ki .apprx. Nanomolar Inhibitors of Serine Proteases Selected by Binding or Chemistry on an Enzyme Surface
  Biochemistry, 1995
• The Hydrolytic Water Molecule in Trypsin, Revealed by Time-Resolved Laue Crystallography
  Science, 1993
• The refined 1.9‐Å X‐ray crystal structure of d‐Phe‐Pro‐Arg chloromethylketone‐inhibited human α‐thrombin: Structure analysis, overall structure, electrostatic properties, detailed active‐site geometry, and structure‐function relationships
  Protein Science, 1992
• Irreversible inhibition of serine proteases by peptide derivatives of (.alpha.-aminoalkyl)phosphonate diphenyl esters
  Biochemistry, 1991
• Catalysis in enzyme crystals
  Trends in Biochemical Sciences, 1988