DRUG-INDUCED BLOOD DYSCRASIAS - 10-YEAR MATERIAL FROM THE SWEDISH-ADVERSE-DRUG-REACTION-COMMITTEE

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 205  (6) , 457-461
Abstract
Drug-induced blood dyscrasias (agranulocytosis, aplastic anemia, hemolytic anemia and thrombocytopenia) in Sweden during a 10 yr period (1966-75) were analyzed. The overall occurrence was remarkably constant, although marked changes occurred regarding offending drugs. Drug-induced thrombocytopenia and agranulocytosis were about twice as common as hemolytic anemia, which in turn was twice as common as aplastic anemia. There was a marked increase with age in the incidence of all drug-induced cytopenias. Women predominated and made up close to 70% of the material. Regarding responsible drugs, the most remarkable finding was the high frequency with which sulfonamides appeared as responsible for all types of drug-induced cytopenia.

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