Plasma Cell Leukemia in BALB/c Mice Inoculated With Subcellular Material. I. Incidence and Morphology2

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Abstract
Plasma cell leukemias have been induced in BALB/c mice after contact with a possible agent from (CBA × DBA/2)F1 mice with transplantable reticular neoplasms. The contact could be via subcellular extracts either directly from the F1 leukemic material or indirectly from tissues of DBA/2 or BALB/c mice which had received the F1 extract, but did not necessarily have recognizable neoplasia. The progeny of BALB/c females inoculated with the suspected leukemogenic agent also had an increased incidence of neoplasia. Inoculation into DBA/2 mice was followed by development of lymphocytic leukemia and some reticulosarcomas. The addition of liver tissue extract with hepatitis agent caused a greater increase in leukemia than the leukemogenic agent alone. The leukemias developed late in life at the same average age as the spontaneous reticular neoplasms of this strain. Since male mice died of amyloidosis before reaching this age, the incidence in males was low except after castration, which caused the males to live as long as females. Paraproteinemia was found in one-third of the mice with plasma cell leukemia. Transplantation of the tumors was successful in all 39 cases attempted.

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