Tissue-specific exposure of chromatin structure at the 5' terminus of the rat preproinsulin II gene.
- 1 March 1981
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 78 (3) , 1577-1580
- https://doi.org/10.1073/pnas.78.3.1577
Abstract
The 5'' terminus of the rat preproinsulin II gene exhibits a tissue-dependent DNase I sensitivity. Only in the chromatin from a pancreatic beta-cell tumor, but not in liver, spleen, kidney, or brain chromatin, is a region at and before the 5'' end of the gene exposed to cleavage. The region of exposure extends 250-300 base-pairs upstream from the 5'' terminus of the preproinsulin mRNA. Such a region may allow control sequences special access to regulatory proteins.This publication has 20 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- Chromatin sub-structure. The digestion of chromatin DNA at regularly spaced sites by a nuclear deoxyribonucleasePublished by Elsevier ,2004
- Chromatin structure of the histone genes of D. melanogasterCell, 1981
- The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase INature, 1980
- Absence of nucleosomes in a fraction of SV40 chromatin between the origin of replication and the region coding for the late leader RNACell, 1980
- The structure and evolution of the two nonallelic rat preproinsulin genesCell, 1979
- The chromatin structure of specific genes: I. Evidence for higher order domains of defined DNA sequenceCell, 1979
- A stretch of “late” SV40 viral DNA about 400 bp long which includes the origin of replication is specifically exposed in SV40 minichromosomesCell, 1979
- Sites in simian virus 40 chromatin which are preferentially cleaved by endonucleasesCell, 1978
- ChromatinNature, 1978