THE EXPERIMENTAL PRODUCTION OF A HYPERCHROMIC ANEMIA IN DOGS WHICH IS RESPONSIVE TO ANTI-PERNICIOUS ANEMIA TREATMENT

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Abstract
The oral adm. of 3 doses daily of choline chloride (10 mg./kg. each) to 5 dogs produced reductions of from 30-43% in their red blood cell counts. Milder anemias were produced in 2 other animals. The anemias, so produced, are hyperchromic and probably are the result of a depression of erythropoiesis. The intramusc. inj. of adequate doses of purified solns. of liver into 3 anemic dogs caused their erythrocyte numbers to respond with increases which were marked by the 7th day, and (in 2 animals) approximated normal after 4 wks. These responses occurred in spite of continued choline adm. Stomach, U.S.P., fed in daily doses of 20 g. to one mildly anemic dog, caused a return of his red cell number and Hb % to normal within 12 days, in spite of continued choline feeding. The oral adm. of atropine sulfate 3 times daily to one anemic dog caused his red cell count to return to normal in 4 wks. in spite of continued choline feeding.

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