Inhibiting Effects of Serotonin Antagonists on the Proliferation of Mercuric Chloride Stimulated Human Peripheral Blood T Lymphocytes
- 1 January 1992
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 97 (2) , 105-108
- https://doi.org/10.1159/000236104
Abstract
The serotonin antagonists ketanserin and methiotepine were tested for a modulating effect on the proliferative response of human peripheral blood T lymphocytes to mercuric chloride. This response was inhibited by ketanserin at 8 × 10––5 mol/l and by methiotepine at 8.0 × 10––6 mol/l. There were no additive effects at these concentrations of antagonists and at 10––5 mol/l of serotonin. Low concentrations of ketanserin eliminated the inhibiting effect of serotonin on mercuric chloride induced proliferation of T lymphocytes. It thus seems as if the inhibiting effect of serotonin on T lymphocytes is mediated by 5-HT1c or 5-HT2 receptors, while the mechanism for the intrinsic inhibiting effect of the antagonists at present is unknown.Keywords
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