Human chromosome hot points
- 1 August 1984
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 67 (3) , 249-251
- https://doi.org/10.1007/bf00291350
Abstract
A chromosome hot point, 3p14, in healthy peasants, mentally retarded patients (MR), and epileptic patients (EP) was studied. The frequency of the hot point, 3p14 break, was significantly higher in EP. It may be caused by folic acid reduction in patients' serum induced by the antiepileptic drugs. The difference between hot point and fragile site is discussed.Keywords
This publication has 11 references indexed in Scilit:
- Methotrexate-induced increase in gap formation in human chromosome band 3p14Hereditas, 2008
- A new heritable fragile site on human chromosome 3Hereditas, 2008
- A new familial ?fragile site? on chromosome 16 (q23-24). Cytogenetic and clinical considerationsHuman Genetics, 1983
- A new inducible fragile site on chromosome 3(p14.2) in human lymphocytesHuman Genetics, 1983
- 5-Fluoro-2'-deoxyuridine induction of the fragile site on Xq28 associated with X linked mental retardation.Journal of Medical Genetics, 1981
- Relationships between serum and cerebrospinal fluid anticonvulsant drug and folic acid concentrations in epileptic patientsNeurology, 1972
- FOLIC ACID AND ANTICONVULSANTSThe Lancet, 1968
- FOLIC ACID AND NEUROPATHY IN EPILEPSYThe Lancet, 1968
- Chromosome Abnormalities in Lymphocytes from Normal Human SubjectsCytogenetic and Genome Research, 1967
- Anticonvulsant Therapy, Folic Acid and Vitamin B12 Metabolism and Mental SymptomsEpilepsia, 1966