THE RATE OF REMOVAL OF INTRAVENOUSLY INJECTED BROMSULPHALEIN BY THE LIVER AND EXTRA HEPATIC TISSUES OF THE DOG

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Abstract
Bradley and associates measured hepatic blood flow in humans using bromsulfalein abstraction from the blood as the basis of their method. This procedure depends upon the supposition that -BSP is removed from blood solely by the liver and organs in the portal circulation. When attempts were made to apply this method to dogs, the following results were obtained: (1) Only 31-65% of intravenously injected bromsulphalein was recovered in the bile of biliary fistula dogs. (2) In the absence of the liver, the gastro-intestinal tract, and the kidneys, injected BSP was removed at constant rates from the blood stream. It was calculated that the peripheral tissues of the dog were capable of removing BSP 25-30% as rapidly as could the intact animal possessing a liver and other portal organs. (3) In the dog, the rate of removal of injected BSP could not be used as an index of blood flow through the liver since this organ is not the sole site of removal of BSP from the blood.

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