G1549, a new cyclic hydroxamic acid antibiotic, isolated from culture broth of Pseudomonas alcaligenes.
- 1 January 1979
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 32 (11) , 1096-1103
- https://doi.org/10.7164/antibiotics.32.1096
Abstract
Antibiotic G1549, isolated from culture broth of P. alcaligenes, is a new cyclic hydroxamic acid with a 1-hydroxy-2(1H)-pyridinone structure that complexes with metals. The structure of G1549 is suggested to be 1-hydroxy-5-methoxy-6-methyl-2(1H)-pyridinone. In vitro, G1549 and its Cu and ferric complexes show moderate activity against gram-positive bacteria, fungi and Trichomonas vaginalis. Topical application of G1549 and its Cu and ferric complexes protect guinea pigs against cutaneous infection with Microsporum canis. The compounds have some systemic toxicity in mice.This publication has 2 references indexed in Scilit:
- G7063-2, a new nitrogen-containing antibiotic of the epoxydon group, isolated from the fermentation broth of a species of Streptomyces.The Journal of Antibiotics, 1977
- Hydroxamic Acids in NatureScience, 1967